Computer simulation helps to explain why HIV treatment is not valid
18. April 2012Genetics magazine study found that early human immunodeficiency virus (HIV) infection,viral load less CDC6 genetic variation, HIV is rapidly evolving to evade the immune and treatment.
Bethesda, MS, March 15, 2012 March, 2012 Genetics published the latest findings onWhy so difficult for HIV treatment. In this paper, an Australian scientist, computer simulation, evolved from an HIV virus group of viruses is how fast evolution, and evade the immune defense. This result is novel because it is contrary to CDCA8 the traditional concept of the previous notion that in that environment, the evolution is very slow. Australia,Adelaide University, Institute of Molecular Biology, the author of CDH1 the study, Dr Jack da Silva, said: "So far, I think that the acquired immune deficiency syndrome (AIDS)treatment failure, because we do not a thorough understanding of how HIV is the evolution of the HIV virus by virtue of the precise genetic mechanism to easily breakthrough the obstacles set up for it, such a mechanism, we need to in-depth study, it is foreseeable, this will provide a new strategy of CDH12 vaccines and other treatments. For thisstudy, da Silva, the application of computer simulation to determine the real case, if agroup of viruses by a single virus copied, then HIV will such a rapid evolution asreported by the building a group of viruses and analog immune system killing infected cells to complete the study due to the small group of viruses, viral gene reorganization and exchange of CDH2 viral gene with the mutation affects the actual situation of cell killing, mutation and reorganization of the scale of the speed and the actual group of viruses isconfirmed even if the initial group of viruses is a single , of HIV also rapidly evolving.
Genetics magazine editor-in-chief, Dr. Mark Johnston, said: cure of HIV / AIDS is still a dream, however, this paper pointed out the reason. Now that we have to understand,even if HIV is very small, it can still be rapid evolution, we may be able to interfere with itthis ability, so that we can take full advantage of the mature treatment.